打印药物复合材料在生物医学中的应用(5)
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背景:运用3D打印技术可将药物与材料结合实现药物联合用药,制成具有特定释放速率的剂型,从而更好的应用于临床。
目的:综述临床常用西药、中药、金属元素及离子等与相关材料制成药物复合材料的制备工艺、优点及适应证等。
方法:由第一作者以“药物;中药或金属;复合材料;3D打印”作为关键词,以“并含”的逻辑组合关系在CNKI、万方数据库进行检索;以“Drug;Chinese medicine;Metal;Composite materials;3D printing”作为关键词,以 “and”的逻辑组合关系在PubMed、Web of Science数据库进行检索,检索时间均为1950至2019年。初步检索文献339篇,筛选后对46篇文献进行分析。
结果与结论:将西药、中药、金属元素及离子等与相关材料制成药物复合材料,在制药领域和临床使用中均有一定的优越性,其不仅可提高药物的生物利用度、降低毒副作用,还可实现联合用药。近年来,药物复合材料已被运用于骨科、牙科、心血管内科、耳鼻喉科等领域,但其应用还处于初级阶段,很多方面需要提高和改进,如提高药物复合材料质量;提高力学稳定性,减少脆性;打印功能齐全,与人体大小相适应的血管和器官;更好地模仿人体真实组织的生物力学、组织结构等。
国家自然科学基金项目(),项目负责人:李伟东;江苏省研究生实践创新计划(SJCX19_0414),项目负责人:侯婧霞
BACKGROUND:Combining drugs with materials using 3D printing technology can be formulated into a dosage form with a specific release rate, which is better for clinical use.
OBJECTIVE:To review the preparation technique, advantages and indications of pharmaceutical composites made from western medicine, traditional Chinese medicine, metal elements and ions and related materials.
METHODS:The first author used the search terms “Drug;Chinese medicine;Metal;Composite materials;3D printing” to search the CNKI and Wanfang databases in Chinese and the PubMed and Web of Science in English to retrieve papers published during 1950-2019. A total of 339 papers were preliminarily retrieved. After screening,46 papers were included in the final analysis.
文章来源:《生物医学工程学杂志》 网址: http://www.swyxgcxzzzz.cn/qikandaodu/2021/0421/554.html
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